Viral protein synthesis in Friend erythroleukemia cell lines
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چکیده
منابع مشابه
Viral protein synthesis in Friend erythroleukemia cell lines.
Viral protein synthesis was studied in two Friend virus-induced erythroleukemia cell lines (Ostertag cell lines FSD1-F4 and B8) by the technique of immuno-precipitation with monospecific antisera to the major envelope glycoprotein gp70 and major core protein p30. One of the cell lines (F4) releases active Friend virus complex to the growth medium, where release of virus from the other cell line...
متن کاملFriend erythroleukemia revisited.
In 1957, Charlotte Friend described a novel retroviral disease in mice characterized by splenic enlargement, erythroleukemia, and death.1 This rapidly progressive disease, now known as Friend disease, has provided a powerful tool for the study of multistage carcinogenesis. Transformed murine erythroleukemia (MEL) cells, isolated from Friend virus–infected mice, have also provided a versatile mo...
متن کاملSynthesis of murine leukemia virus proteins differentiating Friend erythroleukemia cells.
In agreement with previous observations, the Friend 745 line of virus-induced erythroleukemia cells can be induced by dimethyl sulfoxide to synthesize hemoglobin and to increase simultaneously their content of morpho logically recognizable virus particles, especially in cytoplasmic vesicles. In apparent contrast to the electron microscopic results, the cellular content of the major murine leuke...
متن کاملSynthesis of Murine Leukemia Virus Proteins Differentiating Friend Erythroleukemia Cells1
In agreement with previous observations, the Friend 745 line of virus-induced erythroleukemia cells can be induced by dimethyl sulfoxide to synthesize hemoglobin and to increase simultaneously their content of morpho logically recognizable virus particles, especially in cytoplasmic vesicles. In apparent contrast to the electron microscopic results, the cellular content of the major murine leuke...
متن کاملCell-cycle dependence of induced hemoglobin synthesis in Friend erythroleukemia cells temperature-sensitive for growth.
Friend erythroleukemia cells temperature-sensitive (ts) for growth have been used to study the cell-cycle dependence of erythroid differentiation. ts cells accumulated hemoglobin in response to inducer when replicating optimally at permissive temperatures. However, when arrested in the G1 phase of the cell cycle at a nonpermissive temperature, ts cells did not accumulate hemoglobin or globin mR...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1977
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.21.1.328-337.1977